Stem cells in musculoskeletal system for clinical application
نویسندگان
چکیده
منابع مشابه
Concise review: the clinical application of mesenchymal stem cells for musculoskeletal regeneration: current status and perspectives.
Regenerative therapies in the musculoskeletal system are based on the suitable application of cells, biomaterials, and/or factors. For an effective approach, numerous aspects have to be taken into consideration, including age, disease, target tissue, and several environmental factors. Significant research efforts have been undertaken in the last decade to develop specific cell-based therapies, ...
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In the last 15 years, there has been a significant increase in the number of researchers interested in studying Mesenchymal Stem Cells (MSCs). MSCs are self-renewing, heterogenic, and multipotent cells that have multi-lineage potential to differentiate not only in to cell types of mesodermal origin but also other various cell lineage MSCs migrate to inflammatory tissues and apply immunosuppress...
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Stem cell research has obtained much prominence in recent years for its therapeutic potential in dealing with serious diseases, many of which are essentially incurable by routine therapies. Mesenchymal stem cells with pluripotency and immunomodulatory properties are suitable candidates for tissue engineering and regenerative medicine. Today, nanofibrous scaffolds are widely used in tissue en...
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The use of animal models in modeling of human genetic disease has many advantages. In some cases, however, this method may not be applicable due to some limitations, such as differences in tissue composition, anatomy and physiology of humans and animals. Isogenic human disease models are a population of cells that are selected or engineered to model a specific genetic disease, in vitro. They ar...
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Objective(s):To culture thein vitro mouse embryonic stem cells (mESCs) and to direct their differentiation to germ-line cells; in present study we used a vector backbone containing the fusion construct Stra8-EGFP to select differentiated ES cells that entered meiosis. Retinoic acid was used to differentiate embryonic stem cells to germ cells. Materials and Methods: A fragment of Stra8 gene pr...
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ژورنال
عنوان ژورنال: Journal of the Korean Medical Association
سال: 2011
ISSN: 1975-8456
DOI: 10.5124/jkma.2011.54.5.491